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For the ease of use & overall low cost and ease of connectivity, FOC was a…A multicentre randomised controlled trial of fluorouracil, folinic acid and dexamethasone versus fluorouracil, folinic acid and methotrexate in operable non-metastatic breast cancer.
Trials comparing fluorouracil (5FU) and 5FU plus dexamethasone (5FAD) with 5FU and mitoxantrone plus levamisole in the treatment of advanced breast cancer have shown superior therapeutic activity and lesser toxicity with the 5FAD combination. We report a multicentre randomised controlled trial, comparing 5FAD with 5FU alone in the treatment of operable, non-metastatic breast cancer. Ninety patients were randomised to receive 5FU and dexamethasone (5FAD) every two weeks (40 patients) or 5FU alone at the same dose and schedule (50 patients). Fifty-four patients (59.3 per cent) had node-negative disease and 44 (50.5 per cent) had extensive axillary nodal involvement. After 46 patients (50.6 per cent) had completed chemotherapy, 43 (47.8 per cent) were randomised to surgery. Neoadjuvant chemotherapy was begun after confirmation of operability and of the clinical diagnosis of breast cancer. There was no significant difference in overall response rate (46.1 per cent v. 47.3 per cent), time to progression (median 7.5 months v. 7 months), time to relapse (median 21.5 months v. 21 months) or in disease-free survival (median 27 months v. 27 months). No reduction in the time to human growth factor (HGF) levels was seen in the 5FAD arm. One patient in the 5FAD arm and two patients in the 5FU arm had severe complications of chemotherapy, requiring hospitalisation. The 5FAD regimen was well tolerated but had no advantage over the 5FU regimen in the treatment of operable, non-metastatic breast cancer.Latest Customer Reviews
Front. 5:53 min. Show Date No.
U K – Kartuisa is a 2017 Indian Telugu drama film directed by Saket Chaudhary. The film features the Tamil comedian K. Bhagyaraj and Kajal Aggarwal in the lead roles along with Devoleena Bapat, Sheela and newcomer Harish Meher. The music was composed by Anoop Rubens and released under the label of Anuraga Arts. Kartuisa is the official remake of the 2016 Tamil film Enakku Thaane Enakku written and directed by Maari, starring Kathir and Suvalakshmi Haasan, with Kamal Haasan as the producer. This film was produced under the banner of Snout Ltd.
The film received positive to mixed reviews from critics, praising Bhagyaraj’s performance and that of the cinematography while criticizing its slow pace and stereotypical portrayal. The film is a successful remake as it had amassed 90 lakhs at the box office in just 72 days.
On 20 August 2016, it was announced that Tamil director Sudhir would be making his debut in Telugu film industry by directing a film titled Enakku Thaane Enakku which would star Kathir and Suvalakshmi Haasan in the lead roles. Kamal Haasan would also produce the film under his banner Snout Movies. After the unveiling of the title, it was revealed that the film would be a remake of the 2016 Tamil film Enakku Thaane Enakku which was produced by Dhanush, and directed by Maari, starring Kathir and Suvalakshmi Haasan. It is the Tamil version of the 2015 film Madrasapattinam where K. Bhagyaraj had made his debut, also produced by Kathir, and directed by Saket Chaudhary. Chaudhary wanted to remake the Tamil film as he had heard about the story of the film. After the production of the film started, he called Kathir and invited him for the lead role. He considered the film a remake only after he attended the screening of the Tamil film which was released four months prior.
Choudhary developed the concept, script, dialogues, wrote and edited the film, and all other departments of the film were handled by Siva Prasad, who himself had worked as an assistant director for the Tamil film Madrasapattinam. The
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