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The purpose of this randomized, double-blind, placebo-controlled study was to examine the role of training and maintenance of physiological, social, and behavioral contingencies in the efficacy of transdermal nicotine for smoking cessation. Fifty-one smokers received transdermal nicotine (30-mg patch) or placebo patches in a twice-daily dosing regimen for either 13 (n = 30) or 26 (n = 21) weeks and were administered four of five contingency measures (physiological, social, behavioral, self-efficacy, and self-monitoring) twice daily. Participants were less likely to engage in smoking in the real world when transdermal nicotine was administered. Higher levels of daily diary-reported smoking abstinence were observed in transdermal nicotine vs. placebo groups after 13 weeks (8 vs. 5%), after 26 weeks (9 vs. 3%), and at the 52-week follow-up (10 vs. 0%). Baseline smoking abstinence predicted success in the 26-week transdermal nicotine group, but maintenance did not. Participants who received transdermal nicotine during the early phase of the study maintained abstinence at follow-up, whereas those who received placebo patches maintained smoking. Maintenance-associated contingencies may be important in the successful treatment of smoking.Tag: stem cell research
Paul Knoepfler is a Visiting Scientist in the Department
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